Active Nacre
The NACR-45® /125® technology allows the mother-of-pearl shell to be reduced to a micrometric scale: active particles are intact to deploy their full reparative power at the heart of the epidermis and the intestine. The liquid Nacre (mother-of-pearl) extract (extraction of the organic fraction) is a very promising additional ingredient, on which the Group's R&D is already working on.
A patented technology
by MEGA BIOPHARMA
After years of research on the properties of different types of Nacre (mother-of-pearl), Doctors Serge and Georges Camprasse selected a particular type of oyster: the Pinctada maxima. Their research led to the development of a revolutionary natural biomaterial, derived from Nacre (mother-of-pearl). Whether in a solid (cut parts), compact (moulded parts), powdered (powder) or liquid extract form, it promotes the regeneration and repair of hard (bones) and soft (skin, muscles, etc) tissues. To protect this innovative technology, MEGA BIOPHARMA has deployed a strong and sustainable patenting strategy in more than 40 countries.
NACR-45® and NACR-125®
Blue Skincare’s two cross-cutting active ingredients, NACR-45® (topical care) and NACR-125® (dietary supplement), are exclusive ingredients developed and manufactured in the Group's GMP production unit.
A patented technology
by MEGA BIOPHARMA
After years of research on the properties of different types of Nacre (mother-of-pearl), Doctors Serge and Georges Camprasse selected a particular type of oyster: the Pinctada maxima. Their research led to the development of a revolutionary natural biomaterial, derived from Nacre (mother-of-pearl). Whether in a solid (cut parts), compact (moulded parts), powdered (powder) or liquid extract form, it promotes the regeneration and repair of hard (bones) and soft (skin, muscles, etc) tissues. To protect this innovative technology, MEGA BIOPHARMA has deployed a strong and sustainable patenting strategy in more than 40 countries.
NACR-45® and NACR-125®
Blue Skincare’s two cross-cutting active ingredients, NACR-45® (topical care) and NACR-125® (dietary supplement), are exclusive ingredients developed and manufactured in the Group's GMP production unit.
Results of
EX-VIVO studies
With NACR-45®, the skin is stronger
• Strengthening of the cutaneous barrier of healthy skin and improving the radiance of the complexion
• Improvement of the weakened cutaneous barrier of dry skin
WITH NACR-45®, THE SKIN IS CONDITIONED TO REPAIR ITS WOUNDS
Results of
EX-VIVO studies
With NACR-45®, the skin is stronger
• Strengthening of the cutaneous barrier of healthy skin and improving the radiance of the complexion
• Improvement of the weakened cutaneous barrier of dry skin
WITH NACR-45®, THE SKIN IS CONDITIONED TO REPAIR ITS WOUNDS
Mother-of-Pearl Composition
Nacre (Mother-of-pearl) is 100% natural, composed of organic and mineral matter.
• The organic matter accounts for 3 to 5% of the total composition of the shell and is particularly rich in complex lipids (cholesterol, fatty acids, triglycerides, squalene-like lipids, ceramides).
• The mineral matter is a calcium carbonate (in the form of aragonite) and accounts for 95 to 97% of the shell.
Nacre (Mother-of-pearl) is acellular. It does not contain any animal residue (Marin and al. 2020).
Nacre (Mother-of-pearl) has a brick and cement lamellar structure. The intimate partnership between the mineral and organic matrices of Nacre (mother-of-pearl) gives an "ultrastructure", in which the aragonite crystals are like the bricks of a wall and the organic fraction acts as the cement that binds them. This structure is similar to that of the stratum corneum, whose bricks (corneocytes) are linked together by the intercorneocytic cement.
Mother-of-Pearl Composition
Nacre (Mother-of-pearl) is 100% natural, composed of organic and mineral matter.
• The organic matter accounts for 3 to 5% of the total composition of the shell and is particularly rich in complex lipids (cholesterol, fatty acids, triglycerides, squalene-like lipids, ceramides).
• The mineral matter is a calcium carbonate (in the form of aragonite) and accounts for 95 to 97% of the shell.
Nacre (Mother-of-pearl) is acellular. It does not contain any animal residue (Marin and al. 2020).
Nacre (Mother-of-pearl) has a brick and cement lamellar structure. The intimate partnership between the mineral and organic matrices of Nacre (mother-of-pearl) gives an "ultrastructure", in which the aragonite crystals are like the bricks of a wall and the organic fraction acts as the cement that binds them. This structure is similar to that of the stratum corneum, whose bricks (corneocytes) are linked together by the intercorneocytic cement.
Mother-of-Pearl
& Ancient Pharmacopoeia
Nacre (Mother-of-pearl) is an integral part of ancient pharmacopoeia.
In traditional Chinese medicine, Nacre (mother-of-pearl) is used for cosmetic purposes: women used to rub their faces with polished Nacre (mother-of-pearl) to promote blood circulation.
In Central America, the Mayan populations In Central America, the Mayan populations produced Nacre (mother-of-pearl) teeth which they implanted successfully and used Nacre (mother-of-pearl) powder-based preparations to regenerate the skin and promote its repair (scars, sunburns, etc.).
Mother-of-Pearl
& Ancient Pharmacopoeia
Nacre (Mother-of-pearl) is an integral part of ancient pharmacopoeia.
In traditional Chinese medicine, Nacre (mother-of-pearl) is used for cosmetic purposes: women used to rub their faces with polished Nacre (mother-of-pearl) to promote blood circulation.
In Central America, the Mayan populations In Central America, the Mayan populations produced Nacre (mother-of-pearl) teeth which they implanted successfully and used Nacre (mother-of-pearl) powder-based preparations to regenerate the skin and promote its repair (scars, sunburns, etc.).
Mother-of-Pearl
& Scientific Research
At the end of the twentieth century, science takes hold of the Nacre (mother-of-pearl).
In the 80s, the dental surgeons Serge and Georges Camprasse were convinced that Nacre (mother-of-pearl) could replace bone and become an alternative in bone grafting. They are the first to demonstrate the osteogenicity of Nacre (mother-of-pearl): when in contact with Nacre (mother-of-pearl), the bone is able to regenerate. Dozens of scientific publications followed. Today, many universities around the world are carrying out research on Nacre (mother-of-pearl).
In the 2000s, Marthe Rousseau, a CNRS researcher and world specialist in Nacre (mother-of-pearl), published her research on the skin. She determined that the complex lipids of Nacre (mother-of-pearl) participate in the restoration of the cutaneous membrane. In 2008, she demonstrated that the calcium in Nacre (mother-of-pearl) is involved in cell signalling. She is currently conducting research on Nacre (mother-of-pearl) by way of oral consumption, the benefits of which are very promising.
Mother-of-Pearl
& Scientific Research
At the end of the twentieth century, science takes hold of the Nacre (mother-of-pearl).
In the 80s, the dental surgeons Serge and Georges Camprasse were convinced that Nacre (mother-of-pearl) could replace bone and become an alternative in bone grafting. They are the first to demonstrate the osteogenicity of Nacre (mother-of-pearl): when in contact with Nacre (mother-of-pearl), the bone is able to regenerate. Dozens of scientific publications followed. Today, many universities around the world are carrying out research on Nacre (mother-of-pearl).
In the 2000s, Marthe Rousseau, a CNRS researcher and world specialist in Nacre (mother-of-pearl), published her research on the skin. She determined that the complex lipids of Nacre (mother-of-pearl) participate in the restoration of the cutaneous membrane. In 2008, she demonstrated that the calcium in Nacre (mother-of-pearl) is involved in cell signalling. She is currently conducting research on Nacre (mother-of-pearl) by way of oral consumption, the benefits of which are very promising.
Responsible sourcing
Upcycling of the shells
Initially used by the pearl industry (pearl trade), the mother-of-pearl shells of the Pinctada maxima discarded. MEGA BIOPHARMA reuses these pearly shells for bone and skin repair. Through upcycling, these shells find a second life.
A non-endangered species
The Pinctada maxima species was selected by the Camprasse Doctors for its resistant structure, very rich composition and white colour.
• Pinctada maxima is not listed as endangered species in Annex 13 of the Washington Convention on International Trade
• regulation allow the reproduction of the Pinctada maxima in farms
• the cultivation of the Pinctada maxima is economically favourable to the countries that practise it
Responsible sourcing
Upcycling of the shells
Initially used by the pearl industry (pearl trade), the mother-of-pearl shells of the Pinctada maxima discarded. MEGA BIOPHARMA reuses these pearly shells for bone and skin repair. Through upcycling, these shells find a second life.
A non-endangered species
The Pinctada maxima species was selected by the Camprasse Doctors for its resistant structure, very rich composition and white colour.
• Pinctada maxima is not listed as endangered species in Annex 13 of the Washington Convention on International Trade
• regulation allow the reproduction of the Pinctada maxima in farms
• the cultivation of the Pinctada maxima is economically favourable to the countries that practise it