NACR-45®


Healthy skin
Reinforcement of the skin barrier


How does NACR-45® act on the skin barrier?

1• Nacre (mother-of-pearl) induces the expression of 3 key proteins
Type 1 and 2 cytokeratins
Filaggrin which generates NMF (Natural Moisturizing Factors) amino acids and limits PIE (Transepidermal Water Loss)
LCE (Late Cornified Envelop)

2• Nacre (mother-of-pearl) provides constituent lipids of the intercorneocyte cement (Contained in its organic fraction)
Cholesterol, fatty acids and sphingolipids

Result: the skin barrier is reinforced. The skin reflects the light better.

 

How does NACR-45® act on the skin barrier?

1• Nacre (mother-of-pearl) induces the expression of 3 key proteins
Type 1 and 2 cytokeratins
Filaggrin which generates NMF (Natural Moisturizing Factors) amino acids and limits PIE (Transepidermal Water Loss)
LCE (Late Cornified Envelop)

2• Nacre (mother-of-pearl) provides constituent lipids of the intercorneocyte cement (Contained in its organic fraction)
Cholesterol, fatty acids and sphingolipids

Result: the skin barrier is reinforced. The skin reflects the light better.

 

The keratinocyte differentiation process is the cellular process that ensures the implementation of the barrier function of the skin. Within the deep layers of the epidermis, the keratinocytes evolve into corneocytes, cells filled with very hard cytokeratin filaments, aggregated together by filaggrin. The cell membrane of corneocytes transforms into a rigid horny envelope, if it is reinforced by an assembly of key proteins: LCEs (Late Cornified Envelop). It is by inducing the expression of type 1 and 2 cytokeratins, filaggrin and LCE proteins that NACR-45® acts.

Dry skin
Restoration of the skin barrier


How does NACR-45® work?

In the case of dry skin, it is most often filaggrin that is deficient.

NACR-45® induces filaggrin expression
However, filaggrin plays 2 essential roles:
It stimulates the process of keratinocyte differentiation (restoration of the deficient stratum corneum)
It generates the amino acids of NMF (Natural Moisturizing Factors), responsible for the regulation of PIE (Transepidermal Water Loss).

Result: the skin barrier is restored and can fully play its role of defense against the entry of pathogenic substances, such as allergens.

Mutation of the filaggrin gene has been observed in 20 to 50% of patients with atopic dermatitis. Dysfunction of the skin barrier plays an essential role in the pathophysiology of very dry, atopic-prone skin. Filaggrin is the key protein for the implementation of the barrier function and the hydration of the skin.

How does NACR-45® work?

In the case of dry skin, it is most often filaggrin that is deficient.

NACR-45® induces filaggrin expression
However, filaggrin plays 2 essential roles:
It stimulates the process of keratinocyte differentiation (restoration of the deficient stratum corneum)
It generates the amino acids of NMF (Natural Moisturizing Factors), responsible for the regulation of PIE (Transepidermal Water Loss).

Result: the skin barrier is restored and can fully play its role of defense against the entry of pathogenic substances, such as allergens.

Mutation of the filaggrin gene has been observed in 20 to 50% of patients with atopic dermatitis. Dysfunction of the skin barrier plays an essential role in the pathophysiology of very dry, atopic-prone skin. Filaggrin is the key protein for the implementation of the barrier function and the hydration of the skin.


Injured skin
Regeneration of the epidermis


How does NACR-45® work?

In the case of injured skin, NACR-45® acts by stimulating the skin regeneration process by acting at 2 levels:

Epidermal
It reinforces the total re-epithelialization of the wound on the surface (reconstitution of the destroyed epidermis)

Perilesional area
It stimulates dermal reconstruction by inducing:
The synthesis of type I collagen which will help to fill the wound,
The expression of fibronectin , a key protein in the healing process

Thanks to NACR-45® the wound closes well and the scar is beautiful

How does NACR-45® work?

In the case of injured skin, NACR-45® acts by stimulating the skin regeneration process by acting at 2 levels:

Epidermal
It reinforces the total re-epithelialization of the wound on the surface (reconstitution of the destroyed epidermis)

Perilesional area
It stimulates dermal reconstruction by inducing:
The synthesis of type I collagen which will help to fill the wound,
The expression of fibronectin , a key protein in the healing process

Thanks to NACR-45® the wound closes well and the scar is beautiful

In the case of damaged skin, the lost dermis is replaced by new tissue (repair stage), then the lesion closes (epidermis regeneration stage via the migration of keratinocytes). Derived from stem cells of the dermis, fibroblasts participate in its repair. They differentiate, proliferate and migrate to form granulation tissue. Fibroblasts synthesize new components of the ECM (Extra Cellular Matrix): type I and III collagens, GAGs (glycosaminoglycans), proteoglycans, hyaluronic acid and fibronectin.