Reinforcement of the skin barrier
The keratinocyte differentiation process is the cellular process that ensures the implementation of the barrier function of the skin. Within the deep layers of the epidermis, the keratinocytes evolve into corneocytes, cells filled with very hard cytokeratin filaments, aggregated together by filaggrin. The cell membrane of corneocytes transforms into a rigid horny envelope, if it is reinforced by an assembly of key proteins: LCEs (Late Cornified Envelop). It is by inducing the expression of type 1 and 2 cytokeratins, filaggrin and LCE proteins that NACR-45® acts.
Restoration of the skin barrier
Regeneration of the epidermis
In the case of damaged skin, the lost dermis is replaced by new tissue (repair stage), then the lesion closes (epidermis regeneration stage via the migration of keratinocytes). Derived from stem cells of the dermis, fibroblasts participate in its repair. They differentiate, proliferate and migrate to form granulation tissue. Fibroblasts synthesize new components of the ECM (Extra Cellular Matrix): type I and III collagens, GAGs (glycosaminoglycans), proteoglycans, hyaluronic acid and fibronectin.