Results of ex-vivo studies
Healthy skin
Strengthening the skin barrier
How does NACRE ACTIVE-NACR-45® work on the skin barrier?
1• Mother-of-pearl induces the expression of 3 key proteins
Type 1 and 2 cytokeratins
Filaggrin which generates the amino acids of NMF (Natural Moisturizing Factors) and limits TEWL (Insensible Water Loss)
LCE (Late Cornified Envelop)
2• Mother-of-pearl provides lipids constituting intercorneocyte cement (Contained in its organic fraction)
Cholesterol, fatty acids and sphingolipids
Result: the skin barrier is reinforced. The skin reflects light better.
The keratinocyte differentiation process is the cellular process which ensures the establishment of the barrier function of the skin. Within the deep layers of the epidermis, keratinocytes evolve into corneocytes, cells filled with very hard cytokeratin filaments, aggregated together by filaggrin. The cell membrane of corneocytes transforms into a rigid corneal envelope, if it is reinforced by an assembly of key proteins: LCE (Late Cornified Envelop). It is by inducing the expression of type 1 and 2 cytokeratins, filaggrin and LCE proteins that NACRE ACTIVE-NACR-45® acts.
Dry skin
Restoration of the skin barrier
How does NACRE ACTIVE-NACR-45® work?
In the case of dry skin, it is most often filaggrin that is deficient.
NACRE ACTIVE-NACR-45® induces the expression of filaggrin.
However, filaggrin plays 2 essential roles:
It stimulates the process of keratinocyte differentiation (restoration of the deficient stratum corneum)
It generates the amino acids of NMF (Natural Moisturizing Factors), responsible for the regulation of TEWL (Insensible Water Loss).
Result: the skin barrier is restored and can fully play its defense role against the entry of pathogenic substances, such as allergens.
A mutation in the filaggrin gene has been found in 20 to 50% of patients with atopic dermatitis. The dysfunction of the skin barrier plays an essential role in the pathophysiology of very dry skin with atopic tendency. Filaggrin is the key protein for establishing the barrier function and hydration of the skin.
*Ex vivo study on delipidated human skin explants (altered skin barrier model), Application of topical NACRE ACTIVE-NACR-45 ® at 0.5% and 2% for 6 days.
Injured skin
Regeneration of the epidermis
How does NACRE ACTIVE-NACR-45® work?
In the case of damaged skin, NACRE ACTIVE-NACR-45® acts by stimulating the skin regeneration process by acting at 2 levels:
Epidermal
It reinforces the total re-epithelialization of the surface wound (reconstitution of the destroyed epidermis)
Peri-lesional area
It stimulates dermal reconstruction by inducing:
The synthesis of type I collagen which will help to fill the wound
The expression of fibronectin , a key protein in the healing process.
Thanks to NACRE ACTIVE-NACR-45® the wound closes well and the scar is beautiful.
*Ex vivo study on injured human skin explants (healing model), Application of topical NACRE ACTIVE-NACR-45® at 0.5% and 2% for 7 days.
In the case of damaged skin, the lost dermis is replaced by new tissue (repair stage), then the lesion closes (epidermis regeneration stage via the migration of keratinocytes). Coming from stem cells in the dermis, fibroblasts participate in its repair. They differentiate, proliferate and migrate to form granulation tissue. Fibroblasts synthesize new components of the ECM (Extra Cellular Matrix): type I and III collagens, GAGs (glycosaminoglycans), proteoglycans, hyaluronic acid and fibronectin.
