NACR-45®
Healthy skin
Reinforcement of the skin barrier
How does NACR-45® act on the skin barrier?
1• Nacre (mother-of-pearl) induces the expression of 3 key proteins
Type 1 and 2 cytokeratins
Filaggrin which generates NMF (Natural Moisturizing Factors) amino acids and limits PIE (Transepidermal Water Loss)
LCE (Late Cornified Envelop)
2• Nacre (mother-of-pearl) provides constituent lipids of the intercorneocyte cement (Contained in its organic fraction)
Cholesterol, fatty acids and sphingolipids
Result: the skin barrier is reinforced. The skin reflects the light better.
How does NACR-45® act on the skin barrier?
1• Nacre (mother-of-pearl) induces the expression of 3 key proteins
Type 1 and 2 cytokeratins
Filaggrin which generates NMF (Natural Moisturizing Factors) amino acids and limits PIE (Transepidermal Water Loss)
LCE (Late Cornified Envelop)
2• Nacre (mother-of-pearl) provides constituent lipids of the intercorneocyte cement (Contained in its organic fraction)
Cholesterol, fatty acids and sphingolipids
Result: the skin barrier is reinforced. The skin reflects the light better.
Dry skin
Restoration of the skin barrier
How does NACR-45® work?
In the case of dry skin, it is most often filaggrin that is deficient.
NACR-45® induces filaggrin expression
However, filaggrin plays 2 essential roles:
It stimulates the process of keratinocyte differentiation (restoration of the deficient stratum corneum)
It generates the amino acids of NMF (Natural Moisturizing Factors), responsible for the regulation of PIE (Transepidermal Water Loss).
Result: the skin barrier is restored and can fully play its role of defense against the entry of pathogenic substances, such as allergens.
Mutation of the filaggrin gene has been observed in 20 to 50% of patients with atopic dermatitis. Dysfunction of the skin barrier plays an essential role in the pathophysiology of very dry, atopic-prone skin. Filaggrin is the key protein for the implementation of the barrier function and the hydration of the skin.
How does NACR-45® work?
In the case of dry skin, it is most often filaggrin that is deficient.
NACR-45® induces filaggrin expression
However, filaggrin plays 2 essential roles:
It stimulates the process of keratinocyte differentiation (restoration of the deficient stratum corneum)
It generates the amino acids of NMF (Natural Moisturizing Factors), responsible for the regulation of PIE (Transepidermal Water Loss).
Result: the skin barrier is restored and can fully play its role of defense against the entry of pathogenic substances, such as allergens.
Mutation of the filaggrin gene has been observed in 20 to 50% of patients with atopic dermatitis. Dysfunction of the skin barrier plays an essential role in the pathophysiology of very dry, atopic-prone skin. Filaggrin is the key protein for the implementation of the barrier function and the hydration of the skin.
Injured skin
Regeneration of the epidermis
How does NACR-45® work?
In the case of injured skin, NACR-45® acts by stimulating the skin regeneration process by acting at 2 levels:
Epidermal
It reinforces the total re-epithelialization of the wound on the surface (reconstitution of the destroyed epidermis)
Perilesional area
It stimulates dermal reconstruction by inducing:
The synthesis of type I collagen which will help to fill the wound,
The expression of fibronectin , a key protein in the healing process
Thanks to NACR-45® the wound closes well and the scar is beautiful
How does NACR-45® work?
In the case of injured skin, NACR-45® acts by stimulating the skin regeneration process by acting at 2 levels:
Epidermal
It reinforces the total re-epithelialization of the wound on the surface (reconstitution of the destroyed epidermis)
Perilesional area
It stimulates dermal reconstruction by inducing:
The synthesis of type I collagen which will help to fill the wound,
The expression of fibronectin , a key protein in the healing process
Thanks to NACR-45® the wound closes well and the scar is beautiful